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Future Fields
Recombinant Human Prolactin, Fc tag
Regular price
$105.26 USD
Regular price
Sale price
$105.26 USD
Unit price
per
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Powered by people, fly by design. Future Fields’ Recombinant Human Prolactin, Fc tag is ready to support your life-changing research in lactation, cultivated milk products, immune cells, mammary epithelial cells, and beyond.
Key features of Future Fields Recombinant Human Prolactin (PRL-Fc) include:
- Activity: Confirmed functionality using cell proliferation assays
- Uniqueness: Confirmed to be N-glycosylated
- Safety: Confirmed to be negative for mycoplasma and below threshold for endotoxin from Lot-to-Lot – suited for cell culture and preclinical applications
- Price: Product price that is lowest on the market, without compromising quality
Future Fields Recombinant Human Prolactin product consists of Prolactin tagged with the Fc portion of human IgG at the C-terminal end. Fc-tagging is known to enhance stability, solubility and effector function while maintaining multiple ligands’ activity on their cognate receptor.
Comes as lyophilized powder. For research use only.
Synonym
Mammotropin, Luteotropic hormone, Luteotropin, PRL
Description
Human Prolactin, also known by its gene name PRL, is a hormone produced by the pituitary gland. It is primarily responsible for promoting lactation in the mammary glands, but it also has pleiotropic effects in both males and females. Prolactin typically exists in two forms: a glycosylated version and a non-glycosylated version with 23 kDa. Each prolactin molecule is believed to bind with two Prl-receptor molecules. In addition to its role in lactation, peripheral prolactin production is associated with breast and prostate cancer development, regulation of reproductive function, and immune system control. Recent research has suggested that PRL has cytoprotective effects on pancreatic islet cells and liver tissue, which could be crucial for the success of transplantation in clinical settings.
Sequence (monomer):
This protein carries a human IgG Fc tag at the C-terminus with a protease cleavage site linking the protein with the tag. The protein has a calculated MW of 49.8 kDa. Full sequence available upon request.
Purity
Verified by SDS PAGE to be >90% pure
Species
Homo sapiens
Source
Drosophila melanogaster (Why flies?)
Product Documents
Level up your research
Frequently Asked Questions
Are there any cross-species activity with this growth factor?
Yes, even though Human Prolactin-Fc tag shares approximately 60% to 65% similarity with rat and mouse prolactin, it can still trigger prolactin receptors from other species.
Why can’t I see a pellet in the vial?
Lyophilized powder may not be visible for many reasons including, but not limited to, dislodged powder being stuck on the cap or lack of carrier proteins that make the product difficult to see. Please tap or centrifuge the vial to bring all the material down to the bottom and reconstitute the product as outlined above.
Are there any stability concerns with freeze thawing?
Repeated freeze thawing is not recommended, as this may damage the protein products resulting in reduced functionality. After reconstitution, please aliquot into suitable sizes for one time use and freeze.
Can I add BSA as a carrier?
Yes, adding a carrier protein like BSA (0.1%) enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration.
Is this protein bioactive?
Yes, this protein was tested for activity on its cognate receptor via SPR, as well as proliferation of NB2-11 cells.
Are volume discounts or recurring order discounts available for this product?
Yes, please reach out to sales@futurefields.io to discuss your needs.
Sustainability
1% of your purchase proceeds will go towards environmental initiatives.
Scoring 86/100, we achieved the highest level of My Green Lab certification (Green).
Reduce the environmental impact of your research
People
Future Fields is a proud supporter of women in STEM. We would not be here today without the contributions of our female scientists and executives!
Future Fields' Green Team works across departments to build our internal sustainability capacity. Read more about our commitment to sustainability here.
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